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Type: Journal article
Title: Dietary n-3 and n-6 polyunsaturated oils and airway contractility
Author: Abeywardena, M.
Jablonskis, L.
Head, R.
Citation: Prostaglandins, Leukotrienes and Essential Fatty Acids, 2001; 64(4&5):281-287
Publisher: Churchill Livingstone
Issue Date: 2001
ISSN: 0952-3278
Statement of
M.Y. Abeywardena, L.T. Jablonskis and R.J. Head
Abstract: Recent reports suggest modulation of chronic obstructive pulmonary disease by dietary polyunsaturated fatty acids. In the present study, we re-examined this possibility by using an established animal model of pulmonary sensitisation. Adult guinea pigs were fed diets supplemented (10% w/w) with either olive, canola or safflower oil for 4 weeks before sensitising with ovalbumin and continuing on various diets for a further 6 week period. Neither the contraction following ovalbumin challenge, nor the responses to histamine, carbachol and various eicosanoid mediators – prostaglandin F2α, leukotriene C4, thromboxane mimetic U44619 – of isolated segments of airway tissue were altered (P>0.05, ANOVA) by the dietary lipid treatment. Lipid analysis showed changes in membrane linoleic acid (18:2n-6) and α -linolenic acids (α 18:3n-3) in lung phospholipids consistent with dietary intakes. However, no significant further desaturation/elongation of these dietary precursors was evident. Ovalbumin induced contraction was fully reversed by the lipoxygenase inhibitor esculetin whilst indomethacin resulted in a slight increase possibly due to the inhibition of bronchodilator prostanoids. Results confirm that under the conditions employed airway function was not influenced by the variable dietary intakes of n-3 and n-6 PUFA.
Keywords: Lung
Guinea Pigs
alpha-Linolenic Acid
Safflower Oil
Fatty Acids
Leukotriene C4
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Linoleic Acid
Fatty Acids, Monounsaturated
Plant Oils
Cardiovascular Agents
Vasoconstrictor Agents
Analysis of Variance
Dose-Response Relationship, Drug
Dietary Supplements
Lipid Metabolism
Olive Oil
Rapeseed Oil
Rights: © 2001 Harcourt Publishers Ltd
DOI: 10.1054/plef.2001.0272
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Appears in Collections:Aurora harvest 2
Pharmacology publications

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