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Type: Journal article
Title: Some international approaches to aminoglycoside monitoring in the extended dosing interval era
Author: Morris, R.
Sallustio, B.
Vinks, A.
LeGatt, D.
Verjee, Z.
Desoky, E.
Citation: Therapeutic Drug Monitoring, 1999; 21(4):379-388
Issue Date: 1999
ISSN: 0163-4356
Statement of
Raymond G. Morris, Benedetta C. Sallustio, Alexander A. T. M. M. Vinks, Donald F. LeGatt, Zulfikarali H. Verjee, Ehab El Desoky
Abstract: Aminoglycosides have rightly remained a cost-effective anti-microbial strategy for the treatment of Gram-positive infections for some 25 years. However, in recent years there has been a review of the traditional thrice-daily administration regimen in favor of an extended dosing interval strategy that takes into account the individual patient's renal function. The general recommendations that have been provided to date have been adopted in various ways internationally. These approaches were a matter of discussion for the Clinical Pharmacokinetics Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology at its congress (Vancouver, Canada; November 1997), and will again be a workshop issue at the Cairns (Australia) congress of the Association (September 1999). The present report provides examples of how these practices have been applied at a group of centers from Canada (2 centers), The Netherlands, Egypt, and Australia. These reports demonstrate a variety of approaches and highlight the need for further research for assessing clinical outcomes from different dosing strategies.
Keywords: Gentamicin; Aminoglycoside; Therapeutic drug monitoring
Rights: © 1999 Lippincott Williams & Wilkins, Inc.
RMID: 0030003369
DOI: 10.1097/00007691-199908000-00001
Appears in Collections:Pharmacology publications

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