Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14740
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dc.contributor.authorOng, J.en
dc.contributor.authorKerr, D.en
dc.date.issued2000en
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, 2000; 78(6):507-511en
dc.identifier.issn0008-4212en
dc.identifier.issn1205-7541en
dc.identifier.urihttp://hdl.handle.net/2440/14740-
dc.description.abstractIn rat neocortical slices maintained in Mg2+-free Kreb's medium, the effects of Ca2+ concentration on repetitive spontaneous discharges and on GABA(B) receptor-mediated responses were investigated. Over a concentration range of 0.3-2.4 mM Ca2+, there was a reduction of discharge amplitude, with a 50 +/- 6.5% reduction in 0.3 mM Ca2+, whilst the burst frequency remained unaffected. Baclofen, the GABA(B) receptor agonist, produced a concentration-dependent depression of discharge frequency, reversibly antagonised by the antagonist (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (Sch 50911). The EC50 value for baclofen in 2.4 mM Ca2+ was 11 microM, while the EC50 values in 0.3, 0.6, 1.2, and 1.8 mM Ca2+ were 1.3, 2.5, 3.6, and 10 microM, respectively, resulting in 8.5, 4.4, 3.1, and 1.1-fold leftward shifts. This enhanced action of baclofen in low extracellular Ca2+ concentrations in the neocortex may be the result of a lower concentration gradient which reinforces the action of baclofen.en
dc.language.isoenen
dc.publisherNatl Research Council Canadaen
dc.subjectNeocortex; Animals; Rats; Rats, Sprague-Dawley; Calcium Chloride; Baclofen; Receptors, GABA-B; GABA Agonists; Synaptic Transmission; Maleen
dc.titleEffects of Ca2+ concentration on GABAB receptor function in rat neocortical slicesen
dc.typeJournal articleen
dc.identifier.rmid0001000827en
dc.identifier.doi10.1139/y00-017en
dc.identifier.pubid63559-
pubs.library.collectionAnaesthesia and Intensive Care publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Anaesthesia and Intensive Care publications

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