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Type: Journal article
Title: Proteoglycan changes in carcinogen (4WQ0)-Treated tongue mucosa
Author: Wilson, D.
Vreugdenburg, A.
Wiebkin, O.
Citation: Journal Of Oral Pathology and Medicine, 1995; 24(3):113-117
Publisher: Munksgaard, Denmark
Issue Date: 1995
ISSN: 0904-2512
Abstract: The purpose of this study was to undertake preliminary analyses of the extracellular proteoglycans in carcinogen [4-nitroquinoline N-oxide (4NQO)]-treated rat tongue mucosa. Experimental rats were exposed to twice-weekly applications of 4NQO in propylene glycol for six months, after which the animals were killed. Control and 4NQO-treated tissues were subjected to sequential aqueous extractions of proteoglycans under associative and dissociative conditions, followed by alkaline cleavage of protein-glycosaminoglycan linkages to yield a glycosaminoglycan residue. Tissues subjected to 4NQO applications contained smaller proportions of proteoglycans which were readily soluble under associative and dissociative conditions. Proportionately more proteoglycan remained strongly associated with other intercellular tissue components, being released only by alkaline cleavage. These biochemical alterations in preinvasive 4NQO-treated epithelium and connective tissues, together with an observed associated change in water retention by the connective tissue, occurred prior to actual neoplastic invasion and suggest differences in macromolecular conformation and orderliness. We hypothesize that these changes are related to the phenomenon of neoplastic epithelial invasion.
Keywords: Tongue
Connective Tissue
Mouth Mucosa
Body Water
Rats, Inbred Strains
Tongue Neoplasms
Neoplasm Invasiveness
Precancerous Conditions
Extracellular Matrix Proteins
Administration, Topical
DOI: 10.1111/j.1600-0714.1995.tb01150.x
Appears in Collections:Aurora harvest 2
Dentistry publications

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