Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/1588
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dc.contributor.author | Worapamorn, W. | - |
dc.contributor.author | Tam, S. | - |
dc.contributor.author | Li, H. | - |
dc.contributor.author | Haase, H. | - |
dc.contributor.author | Bartold, P. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Periodontal Research, 2002; 37(4):273-278 | - |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.issn | 1600-0765 | - |
dc.identifier.uri | http://hdl.handle.net/2440/1588 | - |
dc.description | Copyright © 2002 Blackwell Munksgaard The definitive version is available at www.blackwell-synergy.com | - |
dc.description.abstract | Cell-surface proteoglycans participate in several biological functions including interactions with a variety of growth factors and cytokines. Regulation of syndecan-1 and -2 gene expression was investigated in human periodontal ligament fibroblasts (PDLF), osteoblasts (OB) and gingival fibroblasts (GF), in response to platelet-derived growth factor (PDGF-BB), transforming growth factor (TGF-beta 1), and interleukin (IL-1 beta) by Northern blot analyses. We also compared the effect of PDGF-BB and TGF-beta 1, separately and in combination, in the prolonged presence of IL-1 beta on the expression of both syndecan genes. The results demonstrated that the three cell lines regulated the expression of syndecan-1 and -2 in response to growth factors and cytokines in different manners. These cell lines increased syndecan-1 mRNA levels in response to either PDGF-BB or TGF-beta 1 and decreased levels in response to IL-1 beta. The effect of IL-1 beta on syndecan-1 mRNA synthesis was partially reversed after adding PDGF-BB and TGF-beta 1, separately or in combination, in the presence of IL-1 beta. In contrast, syndecan-2 mRNA level was markedly upregulated in response to either TGF-beta 1 or IL-1 beta in OB when compared with the other two cell lines. However, the stimulatory effect of TGF-beta 1 on syndecan-2 mRNA production in OB was abolished in the prolonged presence of IL-1 beta. These findings lend support to the notion that syndecan-1 and syndecan-2 have distinct functions which correlate with their source and functions within the periodontium. | - |
dc.description.statementofresponsibility | Worapamorn W; Tam SP; Li H; Haase HR; Bartold PM | - |
dc.language.iso | en | - |
dc.publisher | Munksgaard Int Publ Ltd | - |
dc.source.uri | http://dx.doi.org/10.1034/j.1600-0765.2002.01610.x | - |
dc.subject | Alveolar Process | - |
dc.subject | Fibroblasts | - |
dc.subject | Osteoblasts | - |
dc.subject | Gingiva | - |
dc.subject | Periodontal Ligament | - |
dc.subject | Humans | - |
dc.subject | Proteoglycans | - |
dc.subject | Platelet-Derived Growth Factor | - |
dc.subject | Proto-Oncogene Proteins c-sis | - |
dc.subject | Transforming Growth Factor beta | - |
dc.subject | Membrane Glycoproteins | - |
dc.subject | RNA, Messenger | - |
dc.subject | Interleukin-1 | - |
dc.subject | Cytokines | - |
dc.subject | Blotting, Northern | - |
dc.subject | Cell Culture Techniques | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Up-Regulation | - |
dc.subject | Transforming Growth Factor beta1 | - |
dc.subject | Syndecan-1 | - |
dc.subject | Syndecans | - |
dc.subject | Syndecan-2 | - |
dc.subject | Statistics as Topic | - |
dc.subject | Becaplermin | - |
dc.title | Cytokine regulation of syndecan-1 and -2 gene expression in human periodontal fibroblasts and osteoblasts | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1034/j.1600-0765.2002.01610 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bartold, P. [0000-0002-5695-3877] | - |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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