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|Title:||Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints|
|Citation:||Osteoarthritis and Cartilage, 2001; 9(4):365-370|
|Publisher:||W B Saunders Co Ltd|
|J. I. Ishimaru, N. Ogi, S. Mizuno and A. N. Goss|
|Abstract:||Objective To determine the relationship between synovial fluid, chondroitin sulfate disaccharide and hyaluronic acid to differing degrees of experimental temporomandibular joint (TMJ) osteoarthritis (OA). Design Twenty-four merino sheep were divided into three groups and had different TMJ surgical procedures to produce OA. Group I; control (six sheep), Group II; disc perforation (nine sheep) and Group III; disc perforation and articular damage (nine sheep). Synovial fluid was collected initially and at sacrifice at 3 months. Chondroitin 4-sulfate, chondroitin 6-sulfate and hyaluronic acid were measured and correlated to the OA histologic score. Results The chondroitin-sulfate levels were significantly increased (Group I to Group IIP< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group IIP< 0.01; Group I to Group III P< 0.01) with the increasing OA score. Conclusion Chondroitin-sulfate and hyaluronic acid show a correlation with surgically created TMJ osteoarthritis in sheep model.|
|Keywords:||Temporomandibular joint; Osteoarthritis; Chondroitin sulfate; Hyaluronic acid|
|Description:||Copyright © 2001 OsteoArthritis Research Society International. All rights reserved.|
|Appears in Collections:||Dentistry publications|
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