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Type: Journal article
Title: Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints
Author: Ishimaru, J.
Ogi, N.
Mizuno, S.
Goss, A.
Citation: Osteoarthritis and Cartilage, 2001; 9(4):365-370
Publisher: W B Saunders Co Ltd
Issue Date: 2001
ISSN: 1063-4584
Statement of
J. I. Ishimaru, N. Ogi, S. Mizuno and A. N. Goss
Abstract: Objective To determine the relationship between synovial fluid, chondroitin sulfate disaccharide and hyaluronic acid to differing degrees of experimental temporomandibular joint (TMJ) osteoarthritis (OA). Design Twenty-four merino sheep were divided into three groups and had different TMJ surgical procedures to produce OA. Group I; control (six sheep), Group II; disc perforation (nine sheep) and Group III; disc perforation and articular damage (nine sheep). Synovial fluid was collected initially and at sacrifice at 3 months. Chondroitin 4-sulfate, chondroitin 6-sulfate and hyaluronic acid were measured and correlated to the OA histologic score. Results The chondroitin-sulfate levels were significantly increased (Group I to Group IIP< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group IIP< 0.01; Group I to Group III P< 0.01) with the increasing OA score. Conclusion Chondroitin-sulfate and hyaluronic acid show a correlation with surgically created TMJ osteoarthritis in sheep model.
Keywords: Temporomandibular joint
Chondroitin sulfate
Hyaluronic acid
Description: Copyright © 2001 OsteoArthritis Research Society International. All rights reserved.
DOI: 10.1053/joca.2000.0397
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Dentistry publications

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