Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/16671
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dc.contributor.authorHersey, P.-
dc.contributor.authorMenzies, S.-
dc.contributor.authorCoventry, B.-
dc.contributor.authorNguyen, T.-
dc.contributor.authorFarrelly, M.-
dc.contributor.authorCollins, S.-
dc.contributor.authorHirst, D.-
dc.contributor.authorJohnson, H.-
dc.date.issued2005-
dc.identifier.citationCancer Immunology Immunotherapy, 2005; 54(3):208-218-
dc.identifier.issn0340-7004-
dc.identifier.issn1432-0851-
dc.identifier.urihttp://hdl.handle.net/2440/16671-
dc.description© Springer-Verlag 2004-
dc.description.abstractPrevious studies in small groups of patients suggested that immunization of melanoma patients with peptide epitopes recognized by T cells could induce regression of melanoma. This approach was tested in 36 patients with stage IV melanoma. The (MHC class I– restricted) peptides were from gp100, MART-1, tyrosinase, and MAGE-3. The gp100 and MART-1 peptides had been modified to increase their immunogenicity. In half the patients (groups 3 and 4) the peptides were given in the adjuvant Montanide-ISA-720, and half the patients in both groups were given GM-CSF s.c. for 4 days following each injection. Treatment was well tolerated except for two severe erythematous responses to Montanide- ISA-720 and marked inflammatory responses at sites of GM-CSF administration in three patients. There were no objective clinical responses but stabilization of disease for periods from 3 to 12 months were seen in seven patients. Five of these were patients given the peptides in Montanide-ISA-720. Delayed-type hypersensitivity (DTH) skin test responses were also seen mainly in the patients given the peptides in Montanide- ISA-720. GM-CSF did not increase DTH responses in patients in the latter group but may have increased DTH responses in those not given peptides in Montanide-ISA- 720. Inflammatory responses around s.c. metastases or regional lymph nodes were observed in two patients. These results suggest that the peptides are more effective when given in the adjuvant Montanide-ISA-720. Nevertheless, results from this study, together with those from a number of comparable studies, indicate that peptide vaccines are currently of minimal benefit to patients and support the need for ongoing development of new strategies in treatment of this disease.-
dc.description.statementofresponsibilityPeter Hersey, Scott W. Menzies, Brendon Coventry, Tam Nguyen, Margaret Farrelly, Susan Collins, Debbie Hirst and Heather Johnson-
dc.language.isoen-
dc.publisherSpringer-Verlag-
dc.source.urihttp://dx.doi.org/10.1007/s00262-004-0587-8-
dc.subjectAdjuvants-
dc.subjectClinical responses-
dc.subjectMelanoma-
dc.subjectPeptide vaccines-
dc.subjectT-cell responses-
dc.titlePhase I/II study of immunotherapy with T-cell peptide epitopes in patients with stage IV melanoma-
dc.typeJournal article-
dc.identifier.doi10.1007/s00262-004-0587-8-
pubs.publication-statusPublished-
dc.identifier.orcidCoventry, B. [0000-0002-3596-7735]-
Appears in Collections:Aurora harvest 2
Surgery publications

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