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|Scopus||Web of Science®||Altmetric|
|Title:||Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina|
|Citation:||Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2005; 99(1):39-47|
|Amit Chattopadhyay, Daniel J. Caplan, Gary D. Slade, Diane C. Shugars, Hsaio-Chuan Tien, and Lauren L. Patton|
|Abstract:||<h4>Objectives</h4>To establish incidence rates and risk factors for HIV-associated oral candidiasis (OC), oral hairy leukoplakia (OHL), and any HIV-associated oral diseases (HIV-OD).<h4>Design</h4>This prospective, cumulative case-control study followed 283 initially oral disease-free HIV-1-infected men and women for 2 years. Incidence rate ratios (IRR) and incidence proportions for OC, OHL, and HIV-OD were estimated. Multivariable analyses using Poisson regression determined the most parsimonious best-fitting model explaining the outcomes.<h4>Results</h4>Incidence rate (per 1000 person-months) was 9.3 for OC, 6.8 for OHL, and 13.5 for HIV-OD. Incidence of OC was associated with low CD4 count (adjusted IRR = 3.0 (95% CI = 1.7, 5.1)), smoking (IRR = 1.9 (1.0, 3.8)) and combination antiretroviral therapy (IRR = 0.3 (0.1, 0.8)). Incidence of OHL was associated with low CD4 count, conditional upon smoking status. Conclusions Low CD4 count and smoking are important risk factors for HIV-associated OC and OHL. Antiretroviral medications are protective for OC but not for OHL.|
AIDS-Related Opportunistic Infections
CD4 Lymphocyte Count
|Rights:||© 2005 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Aurora harvest 2|
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