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Type: Journal article
Title: Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina
Author: Chattopadhyay, A.
Caplan, D.
Slade, G.
Shugars, D.
Tien, H.
Patton, L.
Citation: Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2005; 99(1):39-47
Publisher: Mosby Inc
Issue Date: 2005
ISSN: 1079-2104
Statement of
Amit Chattopadhyay, Daniel J. Caplan, Gary D. Slade, Diane C. Shugars, Hsaio-Chuan Tien, and Lauren L. Patton
Abstract: <h4>Objectives</h4>To establish incidence rates and risk factors for HIV-associated oral candidiasis (OC), oral hairy leukoplakia (OHL), and any HIV-associated oral diseases (HIV-OD).<h4>Design</h4>This prospective, cumulative case-control study followed 283 initially oral disease-free HIV-1-infected men and women for 2 years. Incidence rate ratios (IRR) and incidence proportions for OC, OHL, and HIV-OD were estimated. Multivariable analyses using Poisson regression determined the most parsimonious best-fitting model explaining the outcomes.<h4>Results</h4>Incidence rate (per 1000 person-months) was 9.3 for OC, 6.8 for OHL, and 13.5 for HIV-OD. Incidence of OC was associated with low CD4 count (adjusted IRR = 3.0 (95% CI = 1.7, 5.1)), smoking (IRR = 1.9 (1.0, 3.8)) and combination antiretroviral therapy (IRR = 0.3 (0.1, 0.8)). Incidence of OHL was associated with low CD4 count, conditional upon smoking status. Conclusions Low CD4 count and smoking are important risk factors for HIV-associated OC and OHL. Antiretroviral medications are protective for OC but not for OHL.
Keywords: Humans
AIDS-Related Opportunistic Infections
Candidiasis, Oral
Leukoplakia, Hairy
HIV Infections
Anti-HIV Agents
CD4 Lymphocyte Count
Multivariate Analysis
Risk Factors
Regression Analysis
Poisson Distribution
Case-Control Studies
Follow-Up Studies
Prospective Studies
North Carolina
Rights: © 2005 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.tripleo.2004.06.081
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Dentistry publications

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