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https://hdl.handle.net/2440/16769
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dc.contributor.author | Chattopadhyay, A. | - |
dc.contributor.author | Caplan, D. | - |
dc.contributor.author | Slade, G. | - |
dc.contributor.author | Shugars, D. | - |
dc.contributor.author | Tien, H. | - |
dc.contributor.author | Patton, L. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2005; 99(1):39-47 | - |
dc.identifier.issn | 1079-2104 | - |
dc.identifier.issn | 1528-395X | - |
dc.identifier.uri | http://hdl.handle.net/2440/16769 | - |
dc.description.abstract | <h4>Objectives</h4>To establish incidence rates and risk factors for HIV-associated oral candidiasis (OC), oral hairy leukoplakia (OHL), and any HIV-associated oral diseases (HIV-OD).<h4>Design</h4>This prospective, cumulative case-control study followed 283 initially oral disease-free HIV-1-infected men and women for 2 years. Incidence rate ratios (IRR) and incidence proportions for OC, OHL, and HIV-OD were estimated. Multivariable analyses using Poisson regression determined the most parsimonious best-fitting model explaining the outcomes.<h4>Results</h4>Incidence rate (per 1000 person-months) was 9.3 for OC, 6.8 for OHL, and 13.5 for HIV-OD. Incidence of OC was associated with low CD4 count (adjusted IRR = 3.0 (95% CI = 1.7, 5.1)), smoking (IRR = 1.9 (1.0, 3.8)) and combination antiretroviral therapy (IRR = 0.3 (0.1, 0.8)). Incidence of OHL was associated with low CD4 count, conditional upon smoking status. Conclusions Low CD4 count and smoking are important risk factors for HIV-associated OC and OHL. Antiretroviral medications are protective for OC but not for OHL. | - |
dc.description.statementofresponsibility | Amit Chattopadhyay, Daniel J. Caplan, Gary D. Slade, Diane C. Shugars, Hsaio-Chuan Tien, and Lauren L. Patton | - |
dc.language.iso | en | - |
dc.publisher | Mosby Inc | - |
dc.rights | © 2005 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tripleo.2004.06.081 | - |
dc.subject | Humans | - |
dc.subject | AIDS-Related Opportunistic Infections | - |
dc.subject | Candidiasis, Oral | - |
dc.subject | Leukoplakia, Hairy | - |
dc.subject | HIV Infections | - |
dc.subject | Anti-HIV Agents | - |
dc.subject | CD4 Lymphocyte Count | - |
dc.subject | Incidence | - |
dc.subject | Multivariate Analysis | - |
dc.subject | Risk Factors | - |
dc.subject | Regression Analysis | - |
dc.subject | Poisson Distribution | - |
dc.subject | Case-Control Studies | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Prospective Studies | - |
dc.subject | Smoking | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | North Carolina | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tripleo.2004.06.081 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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