Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Occupational risk factors for low grade and high grade glioma: results from an international case control study of adult brain tumours|
|Citation:||International Journal of Cancer, 2005; 113(1):116-125|
|Brigitte Schlehofer, Iris Hettinger, Philip Ryan, Maria Blettner, Susan Preston-Martin, Julian Little, Annie Arslan, Anders Ahlbom, Graham G. Giles, Geoffrey R. Howe, Francoise Ménégoz, Ylva Rodvall, Won N. Choi and Jürgen Wahrendorf|
|Abstract:||The majority of suspected occupational risk factors for adult brain tumours have yet to be confirmed as etiologically relevant. Within an international case-control study on brain tumours, lifelong occupational histories and information on exposures to specific substances were obtained by direct interviews to further investigate occupational risk factors for glioma. This is one of the largest studies of brain tumours in adults, including 1,178 cases and 1987 population controls from 8 collaborating study centres matched for age, gender and centre. All occupational information, was aggregated into 16 occupational categories. In a pooled analysis, odds ratios (OR), adjusted for education, were estimated separately for men and women and for high-grade glioma (HGG) and low-grade glioma (LGG), focusing especially on 6 categories defined a priori: agricultural, chemical, construction, metal, electrical/electronic and transport. For men, an elevated OR of glioma associated with the category metal (OR = 1.24, 95% CI 0.96-1.62) was seen, which appeared to be largely accounted for by LGG (OR = 1.59, 95% CI 1.00-2.52). For the other 5 occupational categories, no elevated risks for glioma were observed. For women the only noteworthy observation for the 6 a priori categories was an inverse association with the agriculture category (OR = 0.60, 95% CI 0.36-0.99). Apart from the 6 major categories, women working in food production or food processing (category food) showed an increased OR of 1.95 (95% CI 1.04-3.68). None of the 20 substance groups was positively associated with glioma risk. Although some other point estimates were elevated, they lacked statistical significance. The results do not provide evidence of a strong association between occupational exposures and glioma development.|
case control study
low grade glioma
high grade glioma
|Description:||Copyright © 2004 Wiley-Liss, Inc.|
|Appears in Collections:||Aurora harvest 2|
Public Health publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.