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https://hdl.handle.net/2440/17143
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Type: | Journal article |
Title: | Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women |
Author: | Need, A. O'Loughlin, P. Horowitz, M. Nordin, B. |
Citation: | Clinical Endocrinology, 2005; 62(6):738-741 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2005 |
ISSN: | 0300-0664 1365-2265 |
Statement of Responsibility: | Allan G. Need, Peter D. O’Loughlin, Michael Horowitz and B. E. Christopher Nordin |
Abstract: | Objective: Because it has been reported that vitamin D, given to mother or infant, can prevent type I diabetes in children, that diabetes is more common in adults with low serum vitamin D and that insulin secretion and action are related to vitamin D levels in healthy young adults we examined the relationship between serum vitamin D metabolites and fasting serum glucose in patients attending our outpatient clinics. Design: Retrospective examination of convenience sample of postmenopausal women attending our osteoporosis clinics. Patients: A total of 753 postmenopausal women attending a university hospital outpatient clinic and not on any treatment known to affect glucose metabolism. Measurements: Body weight and height, serum 25- hydroxyvitamin D [25(OH)D], serum 1,25-dihydroxyvitamin D [1,25(OH) 2 D], serum PTH and fasting serum glucose. Results: On simple correlation fasting serum glucose was a positive function of age (P < 0·05), weight (P < 0·001) and body mass index (BMI) (P < 0·001) and a negative function of serum 25(OH)D (P < 0·001), but it was not significantly related to either serum 1,25(OH) 2 D, PTH or creatinine. When fasting serum glucose was regressed simultaneously on age, BMI and 25(OH)D, glucose was still an inverse function of 25(OH)D (P = 0·006). Conclusions: Fasting serum glucose increased as 25(OH)D levels fell throughout the range of serum 25(OH)D measured but the greatest increase was observed in those with 25(OH)D below 40 nmol/ l. |
Keywords: | Humans Diabetes Mellitus, Type 2 Creatinine Calcifediol Parathyroid Hormone Blood Glucose Vitamin D Body Mass Index Fasting Risk Factors Regression Analysis Postmenopause Adult Aged Aged, 80 and over Middle Aged Female White People |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1111/j.1365-2265.2005.02288.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2265.2005.02288.x |
Appears in Collections: | Aurora harvest 6 Pathology publications |
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