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Type: Journal article
Title: Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
Author: Need, A.
O'Loughlin, P.
Horowitz, M.
Nordin, B.
Citation: Clinical Endocrinology, 2005; 62(6):738-741
Publisher: Blackwell Science Ltd
Issue Date: 2005
ISSN: 0300-0664
Statement of
Allan G. Need, Peter D. O’Loughlin, Michael Horowitz and B. E. Christopher Nordin
Abstract: Objective: Because it has been reported that vitamin D, given to mother or infant, can prevent type I diabetes in children, that diabetes is more common in adults with low serum vitamin D and that insulin secretion and action are related to vitamin D levels in healthy young adults we examined the relationship between serum vitamin D metabolites and fasting serum glucose in patients attending our outpatient clinics. Design: Retrospective examination of convenience sample of postmenopausal women attending our osteoporosis clinics. Patients: A total of 753 postmenopausal women attending a university hospital outpatient clinic and not on any treatment known to affect glucose metabolism. Measurements: Body weight and height, serum 25- hydroxyvitamin D [25(OH)D], serum 1,25-dihydroxyvitamin D [1,25(OH) 2 D], serum PTH and fasting serum glucose. Results: On simple correlation fasting serum glucose was a positive function of age (P < 0·05), weight (P < 0·001) and body mass index (BMI) (P < 0·001) and a negative function of serum 25(OH)D (P < 0·001), but it was not significantly related to either serum 1,25(OH) 2 D, PTH or creatinine. When fasting serum glucose was regressed simultaneously on age, BMI and 25(OH)D, glucose was still an inverse function of 25(OH)D (P = 0·006). Conclusions: Fasting serum glucose increased as 25(OH)D levels fell throughout the range of serum 25(OH)D measured but the greatest increase was observed in those with 25(OH)D below 40 nmol/ l.
Keywords: Humans
Diabetes Mellitus, Type 2
Parathyroid Hormone
Blood Glucose
Vitamin D
Body Mass Index
Risk Factors
Regression Analysis
Aged, 80 and over
Middle Aged
White People
Description: The definitive version is available at
DOI: 10.1111/j.1365-2265.2005.02288.x
Published version:
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