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https://hdl.handle.net/2440/17174
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Type: | Journal article |
Title: | Brain pharmacokinetics of lignocaine before and following intravenous perfluorocarbon emulsion infusion in sheep |
Author: | Doolette, D. Upton, R. Martinez, A. |
Citation: | Clinical and Experimental Pharmacology and Physiology, 2005; 32(5-6):367-371 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2005 |
ISSN: | 0305-1870 1440-1681 |
Abstract: | 1. Perfluorocarbon emulsions have potential medical applications, particularly as temporary oxygen carriers and are likely to be coadministered with other intravenous drugs. It is possible that perfluorocarbon emulsions may alter the disposition of other drugs in the body. 2. In the present study, we examined the brain pharmacokinetics of a 5 min infusion of 100 mg lignocaine in three chronically instrumented sheep before and after the administration of a new investigational perflurocarbon emulsion (Oxygent; Alliance Pharmaceutical, San Diego, CA, USA). 3. The rate constant for the blood : brain equilibration of lignocaine was larger after perflubron administration. This change could not be attributed to a change in brain blood flow and, therefore, may be the result of a change in the free fraction of lignocaine in the blood. |
Keywords: | Brain Animals Sheep Lidocaine Fluorocarbons Infusions, Intravenous Female |
DOI: | 10.1111/j.1440-1681.2005.04197.x |
Published version: | http://dx.doi.org/10.1111/j.1440-1681.2005.04197.x |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 2 |
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