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Type: Journal article
Title: The role of circadian rhythmicity in reproduction
Author: Kennaway, D.
Citation: Human Reproduction Update, 2005; 11(1):91-101
Publisher: Oxford Univ Press
Issue Date: 2005
ISSN: 1355-4786
Statement of
David J. Kennaway
Abstract: Circadian rhythmicity is evident in a wide range of physiological systems including the reproductive axis. The recent discoveries of rhythmic clock gene expression in peripheral tissues, including reproductive tissue, suggests that they may play an important role in optimizing fertility. The evidence for rhythmic control of reproduction from studies in laboratory animals is reviewed and where possible this includes evidence from human studies. Clock genes are highly conserved across species including humans and there is no reason to suggest that they are functionless in humans. The challenge issued here is for researchers to probe their function and the consequences of their disruption in both animal and human reproduction.
Keywords: clock; clock genes; period; shiftwork; suprachiasmatic
Description: © European Society of Human Reproduction and Embryology 2004; all rights reserved
RMID: 0020050037
DOI: 10.1093/humupd/dmh054
Appears in Collections:Obstetrics and Gynaecology publications

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