Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17244
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Type: Journal article
Title: Carbohydrate-restricted diets high in either monounsaturated fat or protein are equally effective at promoting fat loss and improving blood lipids1-3
Author: Luscombe-Marsh, N.
Noakes, M.
Wittert, G.
Keogh, J.
Foster, P.
Clifton, P.
Citation: American Journal of Clinical Nutrition, 2005; 81(4):762-772
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2005
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Natalie D Luscombe-Marsh, Manny Noakes, Gary A Wittert, Jennifer B Keogh, Paul Foster, and Peter M Clifton
Abstract: <h4>Background</h4>When substituted for carbohydrate in an energy-reduced diet, dietary protein enhances fat loss in women. It is unknown whether the effect is due to increased protein or reduced carbohydrate.<h4>Objective</h4>We compared the effects of 2 isocaloric diets that differed in protein and fat content on weight loss, lipids, appetite regulation, and energy expenditure after test meals.<h4>Design</h4>This was a parallel, randomized study in which subjects received either a low-fat, high-protein (LF-HP) diet (29 +/- 1% fat, 34 +/- 0.8% protein) or a high-fat, standard-protein (HF-SP) diet (45 +/- 0.6% fat, 18 +/- 0.3% protein) during 12 wk of energy restriction (6 +/- 0.1 MJ/d) and 4 wk of energy balance (7.4 +/- 0.3 MJ/d). Fifty-seven overweight and obese [mean body mass index (in kg/m(2)): 33.8 +/- 0.9] volunteers with insulin concentrations >12 mU/L completed the study.<h4>Results</h4>Weight loss (LF-HP group, 9.7 +/- 1.1 kg; HF-SP group, 10.2 +/- 1.4 kg; P = 0.78) and fat loss were not significantly different between diet groups even though the subjects desired less to eat after the LF-HP meal (P = 0.02). The decrease in resting energy expenditure was not significantly different between diet groups (LF-HP, -342 +/- 185 kJ/d; HF-SP, -349 +/- 220 kJ/d). The decrease in the thermic effect of feeding with weight loss was smaller in the LF-HP group than in the HF-SP group (-0.3 +/- 1.0% compared with -3.6 +/- 0.7%; P = 0.014). Glucose and insulin responses to test meals improved after weight loss (P < 0.001) with no significant diet effect. Bone turnover, inflammation, and calcium excretion did not change significantly.<h4>Conclusion</h4>The magnitude of weight loss and the improvements in insulin resistance and cardiovascular disease risk factors did not differ significantly between the 2 diets, and neither diet had any detrimental effects on bone turnover or renal function.
Keywords: weight loss; protein; low-carbohydrate diet; energy restriction; insulin resistance; lipids; energy expenditure; appetite; bone turnover; humans
Rights: Copyright © 2005 American Society for Clinical Nutrition
RMID: 0020050299
DOI: 10.1093/ajcn/81.4.762
Published version: http://www.ajcn.org/cgi/content/abstract/81/4/762
Appears in Collections:Obstetrics and Gynaecology publications

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