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Type: Journal article
Title: Anti-mullerian hormone as a marker of ovarian reserve
Author: Tremellen, K.
Kolo, M.
Gilmore, T.
Lekamge, D.
Citation: Australian and New Zealand Journal of Obstetrics and Gynaecology, 2005; 45(1):20-24
Publisher: Blackwell Publishing Asia
Issue Date: 2005
ISSN: 0004-8666
Abstract: <h4>Objective</h4>To analyse the usefulness of plasma anti-mullerian hormone (AMH) measurement as a tool for assessing ovarian reserve in a general infertility population.<h4>Materials and methods</h4>Plasma AMH levels were analysed in 238 women aged 18-46 years during day 3-5 of their menstrual cycle. All 238 patients had follicle stimulating hormone (FSH) levels less than 10 i.u./L, suggesting normal ovarian reserve on traditional FSH criteria. Eighty-seven patients gave their consent to correlate their AMH levels with IVF oocyte retrieval outcome. Patients producing > or = 8 oocytes were classified as having normal ovarian reserve, while those producing < or = 4 oocytes were classified as having poor ovarian reserve.<h4>Results</h4>Plasma AMH levels remained relatively static (20-25 pmol/L) from 18 to 29 years of age. By 30 years of age, plasma AMH levels start to drop rapidly, reaching only 10 pmol/L by 37 years. Despite this 50% fall in AMH levels between 29 and 37 years of age, minimal changes in FSH levels were observed. Using a cut off value of 8.1 pmol/L, plasma AMH assessment could predict poor ovarian reserve on a subsequent IVF cycle with a sensitivity of 80% and a specificity of 85%.<h4>Conclusions</h4>Plasma AMH assessments are superior to FSH in identifying women with reduced ovarian reserve. Anti-mullerian hormone assessment should be considered as a useful adjunct to FSH/oestradiol levels and antral follicle count when estimating ovarian reserve.
Keywords: Ovary
Testicular Hormones
Fertilization in Vitro
Cell Count
Follicular Phase
Middle Aged
Anti-Mullerian Hormone
DOI: 10.1111/j.1479-828X.2005.00332.x
Appears in Collections:Aurora harvest 2
Obstetrics and Gynaecology publications

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