Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||The satiating effect of dietary protein is unrelated to postprandial ghrelin secretion|
|Citation:||Journal of Clinical Endocrinology and Metabolism, 2005; 90(9):5205-5211|
|Lisa J. Moran, Natalie D. Luscombe-Marsh, Manny Noakes, Gary A. Wittert, Jennifer B. Keogh and Peter M. Clifton|
|Abstract:||<h4>Context</h4>Increasing dietary protein relative to carbohydrate and fat enhances weight loss, at least in part by increasing satiety. The mechanism for this is unclear.<h4>Objective</h4>The objective of this study was to compare the effects of isocaloric test meals with differing protein to fat ratios on fasting and postprandial ghrelin, insulin, glucose, appetite, and energy expenditure before and after weight loss on the respective dietary patterns.<h4>Design</h4>The study design was a randomized parallel design of 12 wk of weight loss (6 MJ/d) and 4 wk of weight maintenance (7.3 MJ/d) with meals administered at wk 0 and 16.<h4>Setting</h4>The study was performed at an out-patient research clinic.<h4>Patients and other participants</h4>Fifty-seven overweight (body mass index, 33.8 +/- 3.5 kg/m2) hyperinsulinemic men (n = 25) and women (n = 32) were studied.<h4>Interventions</h4>High-protein/low-fat (34% protein/29% fat) or standard protein/high-fat (18% protein/45% fat) diets/meals were given.<h4>Main outcome measures</h4>The main outcome measures were weight loss and fasting and postprandial ghrelin, insulin, glucose, appetite, and energy expenditure before and after weight loss.<h4>Results</h4>Weight loss (9.2 +/- 0.7 kg) and improvements in fasting and postprandial insulin and glucose occurred independently of diet composition. At wk 0 and 16, subjects wanted less to eat after the high-protein/low-fat than the standard protein/high-fat meal (P = 0.02). Fasting ghrelin increased (157.5 +/- 3.4 pg/ml or 46.6 +/- 1.0 pmol/liter; P < 0.001), and the postprandial ghrelin response improved with weight loss (P = 0.043) independently of diet composition. Postprandial hunger decreased with weight loss (P = 0.018) and was predicted by changes in fasting and postprandial ghrelin (r2 = 0.246; P = 0.004). Lean mass was the best predictor of fasting (r2 = 0.182; P = 0.003) and postprandial ghrelin (r2 = 0.096; P = 0.039) levels.<h4>Conclusions</h4>Exchanging protein for fat produced similar weight loss and improvements in metabolic parameters and ghrelin homeostasis. The reduced appetite observed with increased dietary protein appears not to be mediated by ghrelin homeostasis.|
|Description:||Copyright © 2005 by The Endocrine Society|
|Appears in Collections:||Aurora harvest 6|
Obstetrics and Gynaecology publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.