Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/17284
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Type: | Journal article |
Title: | Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study |
Author: | Annells, M. Hart, P. Mullighan, C. Heatley, S. Robinson, J. McDonald, H. |
Citation: | BMC Pregnancy and Childbirth, 2005; 5(1):WWW1-WWW9 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2005 |
ISSN: | 1471-2393 1471-2393 |
Statement of Responsibility: | Margaret F Annells, Prue H Hart, Charles G Mullighan, Susan L Heatley, Jeffrey S Robinson and Helen M McDonald |
Abstract: | BACKGROUND: Chorioamnionitis is a common underlying cause of preterm birth (PTB). It is hypothesised that polymorphisms in immunoregulatory genes influence the host response to infection and subsequent preterm birth. The relationship between histologic chorioamnionitis and 22 single nucleotide polymorphisms in 11 immunoregulatory genes was examined in a case-control study. METHODS: Placentas of 181 Caucasoid women with spontaneous PTB prior to 35 weeks were examined for histologic chorioamnionitis. Polymorphisms in genes IL1A, IL1B, IL1RN, IL1R1, tumour necrosis factor (TNF), IL4, IL6, IL10, transforming growth factor beta-1 (TGFB1), Fas (TNFRSF6), and mannose-binding lectin (MBL2) were genotyped by polymerase chain reaction and sequence specific primers. Multivariable logistic regression including demographic and genetic variables and Kaplan-Meier survival analyses of genotype frequencies and pregnancy outcome were performed. RESULTS: Sixty-nine (34%) women had histologic evidence of acute chorioamnionitis. Carriage of the IL10-1082A/-819T/592A (ATA) haplotype [Multivariable Odds ratio (MOR) 1.9, P = 0.05] and MBL2 codon 54Asp allele (MOR 2.0, P = 0.04), were positively associated with chorioamnionitis, while the TNFRSF6-1377A/-670G (AG) haplotype (MOR 0.4, P = 0.03) and homozygosity for TGFB1-800G/509T (GT) haplotype (MOR 0.2, P = 0.04) were negatively associated. CONCLUSION: These findings demonstrate that polymorphisms in immunoregulatory genes IL10, MBL2, TNFRSF6 and TGFB1 may influence susceptibility to chorioamnionitis. |
Rights: | © 2005 Annells et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/1471-2393-5-4 |
Published version: | http://www.biomedcentral.com/1471-2393/5/4 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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hdl_17284.pdf | Published version | 403.94 kB | Adobe PDF | View/Open |
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