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https://hdl.handle.net/2440/17384
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Type: | Journal article |
Title: | Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children |
Author: | Roberton, D. Marshall, H. Nolan, T. Sokal, E. Diez-Domingo, J. Flodmark, C. Rombo, L. Lewald, G. de la Flor, J. Casanaovas, J. Verdaguer, J. Mares, J. Van Esso, D. Dieussaert, I. Stoffel, M. |
Citation: | Vaccine, 2005; 23(43):5099-5105 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2005 |
ISSN: | 0264-410X 1873-2518 |
Abstract: | This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7). |
Keywords: | Humans Hepatitis B Hepatitis A Vaccines, Combined Hepatitis A Vaccines Hepatitis B Vaccines Immunization Schedule Drug Administration Schedule Child Child, Preschool Infant |
DOI: | 10.1016/j.vaccine.2005.06.003 |
Published version: | http://dx.doi.org/10.1016/j.vaccine.2005.06.003 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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