Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17384
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Type: Journal article
Title: Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children
Author: Roberton, D.
Marshall, H.
Nolan, T.
Sokal, E.
Diez-Domingo, J.
Flodmark, C.
Rombo, L.
Lewald, G.
de la Flor, J.
Casanaovas, J.
Verdaguer, J.
Mares, J.
Van Esso, D.
Dieussaert, I.
Stoffel, M.
Citation: Vaccine, 2005; 23(43):5099-5105
Publisher: Elsevier Sci Ltd
Issue Date: 2005
ISSN: 0264-410X
1873-2518
Abstract: This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).
Keywords: Humans; Hepatitis B; Hepatitis A; Vaccines, Combined; Hepatitis A Vaccines; Hepatitis B Vaccines; Immunization Schedule; Drug Administration Schedule; Child; Child, Preschool; Infant
RMID: 0020051097
DOI: 10.1016/j.vaccine.2005.06.003
Appears in Collections:Paediatrics publications

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