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|Title:||Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children|
de la Flor, J.
Van Esso, D.
|Citation:||Vaccine, 2005; 23(43):5099-5105|
|Publisher:||Elsevier Sci Ltd|
|Abstract:||This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).|
|Keywords:||Humans; Hepatitis B; Hepatitis A; Vaccines, Combined; Hepatitis A Vaccines; Hepatitis B Vaccines; Immunization Schedule; Drug Administration Schedule; Child; Child, Preschool; Infant|
|Appears in Collections:||Paediatrics publications|
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