Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17397
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Type: Journal article
Title: Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart
Author: Cleland, L.
Gibson, R.
Pedler, J.
James, M.
Citation: Lipids, 2005; 40(10):995-998
Publisher: Amer Oil Chemists Soc A O C S Press
Issue Date: 2005
ISSN: 0024-4201
1558-9307
Statement of
Responsibility: 
Leslie G. Cleland, Robert A. Gibson, Janet Pedler, and Michael J. James
Abstract: Flaxseed, echium, and canola oils contain α-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator. Despite canola oil having the lowest ALA content of the three n-3-containing vegetable oils, it was the most potent for elevating DHA (22:6n-3) levels in rat hearts and plasma. However, the relative potencies of the dietary oils for elevation of EPA (20:5n-3) in heart and plasma followed the same rank order as their ALA content, i.e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Δ6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation.
Keywords: Myocardium; Heart; Animals; Rats; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; alpha-Linolenic Acid; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, Unsaturated; Arachidonic Acid; Fatty Acids, Omega-6; Phospholipids; Plant Oils; Female
Description: The original publication can be found at www.springerlink.com
RMID: 0020051394
DOI: 10.1007/s11745-005-1461-6
Published version: http://www.springerlink.com/content/g10q657453442411/fulltext.pdf
Appears in Collections:Paediatrics publications

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