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|Title:||Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart|
|Citation:||Lipids, 2005; 40(10):995-998|
|Publisher:||Amer Oil Chemists Soc A O C S Press|
|Leslie G. Cleland, Robert A. Gibson, Janet Pedler, and Michael J. James|
|Abstract:||Flaxseed, echium, and canola oils contain α-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator. Despite canola oil having the lowest ALA content of the three n-3-containing vegetable oils, it was the most potent for elevating DHA (22:6n-3) levels in rat hearts and plasma. However, the relative potencies of the dietary oils for elevation of EPA (20:5n-3) in heart and plasma followed the same rank order as their ALA content, i.e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Δ6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation.|
|Keywords:||Myocardium; Heart; Animals; Rats; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; alpha-Linolenic Acid; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, Unsaturated; Arachidonic Acid; Fatty Acids, Omega-6; Phospholipids; Plant Oils; Female|
|Description:||The original publication can be found at www.springerlink.com|
|Appears in Collections:||Paediatrics publications|
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