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Type: Journal article
Title: Clozapine improves working memory updating in schizophrenia
Author: Galletly, C.
Clark, C.
McFarlane, A.
Citation: European Neuropsychopharmacology, 2005; 15(6):601-608
Publisher: Elsevier Science BV
Issue Date: 2005
ISSN: 0924-977X
Statement of
Cherrie A. Galletly, C. Richard Clark and Alexander C. McFarlane
Abstract: This study investigated the effect of clozapine on working memory in 15 subjects with schizophrenia, using an event related potential paradigm designed to separate components reflecting working memory updating from components related to target detection and response. Compared to matched controls and prior to treatment with clozapine, subjects with schizophrenia had N1, P3 and Late Slow Wave abnormalities indicating impairment in early stimulus evaluation and subsequent working memory functions. Treatment with clozapine was associated with normalization of the P3 and Late Slow Waves, indicating improvement in working memory updating and executive processing. There was also a partial normalization of N1 amplitude, suggesting improvement in early stimulus evaluation.
Keywords: Schizophrenia; Cognition; Memory; Clozapine; Event related potential; P3
Description: Copyright © 2005 Elsevier B.V. and ECNP All rights reserved.
RMID: 0020051436
DOI: 10.1016/j.euroneuro.2005.03.001
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Appears in Collections:Psychiatry publications

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