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Type: Journal article
Title: Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist
Author: Jensen, J.
Lehmann, A.
Uvebrant, A.
Carlsson, A.
Jerndal, G.
Nilsson, K.
Flach, C.
Blackshaw, L.
Mattsson, J.
Citation: Behavioural Processes, 2005; 519(1-2):154-157
Publisher: Elsevier Science BV
Issue Date: 2005
ISSN: 0014-2999
Statement of
Jörgen Jensen, Anders Lehmann, Anna Uvebrant, Anita Carlsson, Gunilla Jerndal, Karolina Nilsson, Claudine Frisby, L. Ashley Blackshaw, Jan P. Mattsson
Abstract: Transient lower esophageal sphincter relaxation is the major mechanism for gastroesophageal reflux. The present study was initiated to investigate the potential effect of the metabotropic glutamate 5 (mGlu5) receptor antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), on transient lower esophageal sphincter relaxations in the conscious dog. MPEP (1.4-8.7 micromol/kg i.v.) produced a dose-dependent inhibition of transient lower esophageal sphincter relaxations (59+/-11% inhibition at 8.7 micromol/kg). In addition, there was a reduction of the number of reflux episodes and an increase in latency time to the occurrence of the first transient lower esophageal sphincter relaxation. No effect was seen on basal lower esophageal sphincter pressure or on swallowing. It is concluded that the mGlu5 receptor antagonist MPEP potently inhibits transient lower esophageal sphincter relaxations and that the mGlu5 receptor is a potential target for treatment of gastroesophageal reflux disease.
Keywords: Glutamate
Lower esophageal sphincter
Gastroesophageal reflux
DOI: 10.1016/j.ejphar.2005.07.007
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