Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17654
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Type: Journal article
Title: Immunosuppressant drug monitoring: Is the laboratory meeting clinical expectations?
Author: Morris, R.
Citation: Annals of Pharmacotherapy, 2005; 39(1):119-127
Publisher: Harvey Whitney Books Co
Issue Date: 2005
ISSN: 1060-0280
1542-6270
Abstract: <h4>Objective</h4>To review the literature relating to immunosuppressant drug measurement as performed in therapeutic drug monitoring laboratories associated with transplantation centers and consider whether the assay methods widely used for patient dosage management achieve acceptable quality criteria in the context of other sources of variability with these drugs.<h4>Data sources</h4>Articles used were accessed primarily through MEDLINE, as well as references cited in related publications. Searches were restricted to organ transplantation in humans.<h4>Study selection and data extraction</h4>Emphasis was placed on the literature relating to the quality of immunosuppressant drug assays, their limitations, and evidence of clinical benefit in dosage individualization.<h4>Data synthesis</h4>There is a dilemma evident between the quality of the analytical services offered by some diagnostic immunoassay manufacturers and the ability of a significant number of clinical laboratories globally to select only appropriate assay methods.<h4>Conclusions</h4>In many cases, clinical laboratories fail to meet the reasonable clinical expectations required for interpretation of immunosuppressant drug assay results as an adjunct to optimal dosage individualization and patient care.
Keywords: Humans; Mycophenolic Acid; Sirolimus; Tacrolimus; Cyclosporine; Immunosuppressive Agents; Drug Monitoring; Transplantation; Quality Control; Laboratories
RMID: 0020050056
DOI: 10.1345/aph.1E287
Appears in Collections:Pharmacology publications

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