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dc.contributor.authorO'Donovan, D.en
dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorChong, C.en
dc.contributor.authorCameron, A.en
dc.contributor.authorTonkin, A.en
dc.contributor.authorWishart, J.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.identifier.citationJournals of Gerontology Series A-Biological Sciences and Medical Sciences, 2005; 60(7):940-946en
dc.description.abstractOBJECTIVES:Postprandial hypotension occurs frequently in older people and may result in syncope and falls. It has recently been established that the magnitude of the fall in blood pressure is related to the rate at which glucose enters the small intestine. We addressed the hypothesis that the fall in blood pressure induced by an intraduodenal glucose infusion is influenced by the interaction of glucose with the small intestinal absorptive epithelium. METHODS:Eight healthy older participants (four male, four female, age 70.3 +/- 3.4 years) were studied on two separate occasions, in single-blind, randomized order. Participants received an intraduodenal glucose infusion (3 kcal/min) with or without guar gum (4 g) for 60 minutes (0-60 minutes), followed by 0.9% saline intraduodenally for a further 60 minutes (60-120 minutes). Blood pressure and heart rate were measured every 3 minutes. Levels of blood glucose, plasma insulin, glucagon-like peptide-1 (GLP-1), and glucose-dependant insulinotropic-polypeptide (GIP) were also determined. RESULTS:Between t = 0 and t = 30 minutes, the magnitude of the fall in systolic blood pressure (p =.03) and increase in heart rate (p =.027) were lower after guar. The blood glucose (p =.009), plasma insulin (p =.027), plasma GLP-1 (p =.018), and GIP (p <.001) responses to intraduodenal glucose were attenuated by guar. CONCLUSIONS:In healthy older participants, the magnitude of the fall in systolic blood pressure and increase in heart rate induced by intraduodenal glucose are attenuated when the exposure of glucose to the small intestinal mucosa and subsequent glucose absorption is slowed by guar.en
dc.description.statementofresponsibilityDeirdre O'Donovan, Christine Feinle-Bisset, Chilton Chong, Alexander Cameron, Anne Tonkin, Judith Wishart, Michael Horowitz and Karen Louise Jonesen
dc.publisherGerontological Society of Americaen
dc.rightsCopyright © 2005 by The Gerontological Society of Americaen
dc.subjectDuodenum; Humans; Hypotension; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Glucose; Blood Glucose; Galactans; Mannans; Peptide Fragments; Protein Precursors; Sweetening Agents; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Single-Blind Method; Blood Pressure; Heart Rate; Postprandial Period; Time Factors; Reference Values; Aged; Female; Male; Glucagon-Like Peptide 1; Plant Gums; Biomarkersen
dc.titleIntraduodenal guar attenuates the fall in blood pressure induced by glucose in healthy older adultsen
dc.typeJournal articleen
pubs.library.collectionPharmacology publicationsen
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidCameron, A. [0000-0002-5574-2568]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
Appears in Collections:Pharmacology publications

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