Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Relationships between sirolimus dosing, concentration and outcomes in renal transplant recipients|
|Citation:||British Journal of Clinical Pharmacology, 2005; 60(5):560-565|
|Publisher:||Blackwell Publishing Ltd|
|Abstract:||<h4>Aim</h4>To explore relationships between sirolimus dosing, concentration and clinical outcomes.<h4>Methods</h4>Data were collected from 25 kidney transplant recipients (14 M/11 F), median 278 days after transplantation. Outcomes of interest were white blood cell (WBC) count, platelet (PLT) count, and haematocrit (HCT). A naive pooled data analysis was performed with outcomes dichotomized (Mann-Whitney U-tests).<h4>Results</h4>Several patients experienced at least one episode when WBC (n = 9), PLT (n = 12), or HCT (n = 21) fell below the lower limits of the normal range. WBC and HCT were significantly lower (P < 0.05) when sirolimus dose was greater than 10 mg day(-1), and sirolimus concentration greater than 12 microg l(-1). No relationship was shown for PLT and dichotomized sirolimus dose or concentration.<h4>Conclusions</h4>Given this relationship between sirolimus concentration and effect, linked population pharmacokinetic-pharmacodynamic modelling using data from more renal transplant recipients should now be used to quantify the time course of these relationships to optimize dosing and minimize risk of these adverse outcomes.|
Dose-Response Relationship, Drug
|Appears in Collections:||Aurora harvest 2|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.