Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17684
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dc.contributor.authorAnderson, R.en
dc.contributor.authorBrown, C.en
dc.contributor.authorBlumbergs, P.en
dc.contributor.authorMcLean, A.en
dc.contributor.authorJones, N.en
dc.date.issued2003en
dc.identifier.citationJournal of Neurotrauma, 2003; 20(10):961-974en
dc.identifier.issn0897-7151en
dc.identifier.issn1557-9042en
dc.identifier.urihttp://hdl.handle.net/2440/17684-
dc.description© Mary Ann Liebert, Inc.en
dc.description.abstractThis paper describes a biomechanical study of axonal injury due to a blunt impact to the head. The aim of the experimental model was to produce axonal injury analogous to that seen in human trauma while measuring the dynamics of the impact and the subsequent kinematics of the head. These measurements were made in a way to facilitate the simulation of these experiments using the finite element method. Sheep were anaesthetised and ventilated, and subjected to a single impact to the lateral aspect of their skull. The impact force was measured throughout the duration of the impact and the kinematics of the head was measured using a novel implementation of a nine-accelerometer array. The axonal injury was identified using amyloid precursor protein (APP) as a marker, intensified using antigen retrieval techniques. Axonal injury was consistently produced in all animals. Commonly injured regions included the sub-cortical and deep white matter, and the periventricular white matter surrounding the lateral ventricles. The observed axonal injury was mapped and quantified on three coronal sections of each brain. The measure used to describe the injury severity correlated with the peak magnitude of the impact force and with peak values of kinematic parameters, particularly the peak change of linear and angular velocity.en
dc.description.statementofresponsibilityRobert W.G. Anderson, Christopher J. Brown, Peter C. Blumbergs, A. Jack McLean, Nigel R. Jonesen
dc.language.isoenen
dc.publisherMary Ann Liebert Inc Publen
dc.source.urihttp://www.liebertonline.com/doi/abs/10.1089/089771503770195812en
dc.subjectAxonal injury; Biomechanics; Amyloid precursor protein; Head impacten
dc.titleImpact mechanics and axonal injury in a sheep modelen
dc.typeJournal articleen
dc.identifier.rmid0020031075en
dc.identifier.doi10.1089/089771503770195812en
dc.identifier.pubid58417-
pubs.library.collectionSurgery publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidAnderson, R. [0000-0003-1306-6239]en
Appears in Collections:Surgery publications
Pathology publications
Centre for Automotive Safety Research publications

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