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https://hdl.handle.net/2440/17913
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Type: | Journal article |
Title: | Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes |
Author: | Hendrickson, K. Geue, J. Wyness, O. Lincoln, S. Ward, A. |
Citation: | Journal of the American Chemical Society, 2003; 125(13):3889-3895 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2003 |
ISSN: | 0002-7863 1520-5126 |
Statement of Responsibility: | Kym M. Hendrickson, Jason P. Geue, Oska Wyness, Stephen F. Lincoln, and A. David Ward |
Abstract: | A potentiometric study of the coordination of the fluorophore, 2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxyacetic acid, (1)LH(2) (the intracellular Zn(2+) probe, Zinquin A) in its deprotonated form, (1)L(2)(-), in Zn(2+) ternary complexes, [Zn(n)L(1)L](n) (where n is the charge of (n)L) at 298.2 K in 50% aqueous ethanol (v/v) and I = 0.10 (NaClO(4)), shows that the formation of [Zn(n)L(1)L](n) from [Zn(n)L]((2+)(n)(+) is characterized by log(K(5)/dm(3) mol(-1)) = 8.23 +/- 0.05, 4.36 +/- 0.18, 8.45 +/- 0.10, 10.00 +/- 0.06, 11.53 +/- 0.06 and 5.92 +/- 0.15, respectively, where (n)L = (2)L - (6)L and (7)L(3-) are 1,4,7,10-tetraazacyclododecane, 1,4,8,11-tetraazacyclotetradecane, 1,4,7-triazacyclononane, 1,5,9-triazacyclododecane, tris(2-aminoethyl)amine and nitrilotriacetate, respectively, and K(5) is the stepwise complexation constant. Dissociation of a hydroxo proton from triethanolamine, (8)L, occurs in the formation of [Zn(8)LH(-1)](+) that subsequently forms [Zn(8)LH(-1)(1)L](-) for which log(K(5)/dm(3) mol(-1)) = 9.87 +/- 0.08. The variation of K(5) and the 5-fold variation of quantum yield of (1)L(2)(-) as its coordination environment changes in Zn(2+) ternary complexes are discussed with reference to the use of (1)L(2-) in the detection of intracellular Zn(2+). |
Keywords: | Zinc Tosyl Compounds Quinolones Fluorescent Dyes Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Potentiometry Kinetics Hydrogen-Ion Concentration |
Description: | Copyright © 2003 American Chemical Society |
DOI: | 10.1021/ja020685y |
Published version: | http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2003/125/i13/abs/ja020685y.html |
Appears in Collections: | Aurora harvest 2 Chemistry publications Environment Institute publications |
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