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Type: Journal article
Title: Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas
Author: Marcu, L.
Van Doorn, T.
Olver, I.
Citation: Physics in Medicine and Biology, 2004; 49(16):3767-3779
Publisher: IOP Publishing
Issue Date: 2004
ISSN: 0031-9155
Statement of
L Marcu, T van Doorn and I Olver
Abstract: The mechanisms postulated to be responsible for the accelerated repopulation of squamous cell carcinomas during radiotherapy are the loss of asymmetry of stem cell division, acceleration of stem cell division, abortive division and/or recruitment of the non-cycling cell with proliferative capacity. Although accelerated repopulation was observed with recruitment and accelerated cell cycles, it was not sufficient to cause an observable change to the survival curve. However, modelling the loss of asymmetry in stem cell division has reshaped the curve with a 'growth' shoulder. Cell recruitment was not found to be a major contributor to accelerated tumour repopulation. A more significant contribution was provided through the multiplication of surviving tumour stem cells during radiotherapy, by reducing their cell cycle time, and due to loss of asymmetry of stem cell division.
Keywords: Stem Cells
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Radiotherapy Dosage
Cell Cycle
Cell Division
Cell Proliferation
Cell Survival
Radiation Tolerance
Models, Theoretical
Time Factors
Dose Fractionation, Radiation
Rights: Copyright © 2004 IOP Publishing
DOI: 10.1088/0031-9155/49/16/021
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Appears in Collections:Aurora harvest 6
Physics publications

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