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|Title:||Remodelling of high density lipoproteins by plasma factors / by Hui-Qi Liang.|
|School/Discipline:||Dept. of Medicine|
|Abstract:||This thesis examines the effect of remodelling HDL on the metabolism of apo A-I. The major focus is on the effects of CETP and LCAT in the regulation of apo A-I concentration in DHL. The effects of incubation of HDL with CETP in the presence of VLDL and/or LDL on apo A-I concentration in HDL are examined. The characterization of the dissociated apo A-I from HDL is presented. The studies demonstrate that the dissociation of apo A-I from HDL mediated by CETP is preventable and reversible in a process dependent on LCAT activity. The mechanism by which HDL apo A-I content is increased is also explored.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1997?|
|Subject:||High density lipoproteins.|
|Description:||Bibliography: leaves 105-151.|
xi, 151,  leaves,  leaves of plates : ill. ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals|
|Appears in Collections:||Research Theses|
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|02whole.pdf||8.83 MB||Adobe PDF||View/Open|
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