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|Title:||The attachment of dyes to amino acids / by Michael John Millan.|
|Author:||Millan, Michael John|
|School/Discipline:||Dept. of Chemistry|
|Abstract:||This thesis aims to attach dyes to amino acids in a protein. The study examines the 1,4-addition (Michael type) of the nucleophilic groups present in a protein onto a conjugated alkyne reactive group bound to a dye moiety. The initial studies examine the reactivity of individual amino acids with nucleophilic side chains which are common in proteins towards conjugated alkynes. The second stage of the project requires the synthesis of a series of compounds such as those where a dye is attached to a conjugated alkyne via a spacer unit. The reactivity of these compounds with the individual amino acids is studied, as well as the attachment of compounds of this type to, initially, short peptides, and later to a protein such as wool.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1997?|
|Description:||Bibliography: leaves 167-176.|
viii, 176 leaves : ill. ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals.|
|Appears in Collections:||Research Theses|
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|02whole.pdf||2.42 MB||Adobe PDF||View/Open|
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