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Type: Thesis
Title: LDL receptor regulation in human liver cells by dietary fatty acids and antioxidants / Sebely Pal.
Author: Pal, Sebely
Issue Date: 1996
School/Discipline: Dept. of Animal Sciences
Abstract: Demonstrates that fatty acids and antioxidants can regulate the low density lipoprotein (LDL) receptor at the level of gene transcription in cultured liver cells. EPA and linoleic acid (PUFAs) are specifically shown to downregulate the LDL receptor compared to saturated and monosaturated fatty acids in the presence or absence of cholesterol. The experiments lead to the discovery that antioxidants can upregulate the LDL receptor in the human HepG2 cells.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Science, 1996
Subject: Low density lipoproteins Receptors.
Fatty acids.
Cholesterol Metabolism.
Description: Erratum final three leaves of thesis.
Includes bibliographical references (leaves 266-288).
xvi, 288, [3] leaves : ill. ; 30 cm.
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
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