Adelaide Research & Scholarship
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https://hdl.handle.net/2440/19022
| Type: | Thesis |
| Title: | The characterisation of human X-linked polymorphic markers and their use in disease gene localisation and identification / Andrew James Donnelly. |
| Author: | Donnelly, Andrew James |
| Issue Date: | 1997 |
| School/Discipline: | Dept. of Genetics |
| Abstract: | The aim of the project presented in this thesis is to isolate microsatellite markers and to construct a high resolution genetic map of the human X chromosome using these and pre-existing microsatellite markers. AC dinucleotide repeat markers are isolated from a bacteriophage library for application to the genetic localisations of X-linked disease genes, particularly those responsible for non-specific mental retardation (MRX). The genetic map is used to refine the location of the disease gene segregating in five families affected with X-linked mental retardation. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Genetics, 1997 |
| Subject: | Human gene mapping. Genetics Research. Fragile X syndrome. X chromosome Abnormalities. Mental retardation. |
| Description: | Copies of author's previously published works inserted. Bibliography: leaves 321-370. xv, 370, [21] leaves : ill. (chiefly col.) ; 30 cm. |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text. |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 46.94 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 17.98 MB | Adobe PDF | View/Open | |
| Permissions Restricted Access | Library staff access only | 831.05 kB | Adobe PDF | View/Open |
| Restricted Restricted Access | Library staff access only | 21.63 MB | Adobe PDF | View/Open |
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