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|A multivariate exploration of the South Australian prenatal Down's syndrome screen / Brent Henderson.
|Dept. of Statistics
|This thesis considers several aspects of multivariate analysis motivated by the South Australian prenatal Down's syndrome screen, which seeks to identify those pregnancies at high risk to Down's syndrome from several risk factors, amongst them maternal age and measurements from four analyte concentrations found in maternal blood. The primary aim is to discriminate between the unaffected and affected pregnancies in terms of these observed risk factors. Through the development of multivariate regression models it is examined how the Mahalanobis distance might be decomposed into distances that give more insight into where the discrimination is derived and how this might change with the gestational age at which the analyte concentrations are measured. A second multivariate aspect motivated by the screen surrounds the detection of directional outliers and the incorporation of knowledge of likely departures into the outlier identification technique. A method is also developed to account for misreporting in inferences of gestational age. Similarities with measurement error and misclassification models are explored.
|Thesis (Ph.D.)--University of Adelaide, Dept. of Statistics, 1998?
|Down syndrome Diagnosis Statistical methods.
Medical screening South Australia Statistical methods.
|Bibliography: leaves 223-229.
xiii, 229 leaves : ill. ; 30 cm.
|This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
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