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Type: Thesis
Title: Targeted transgenesis and the 186 site-specific recombination system / by Sharon Jane Harrison.
Author: Harrison, Sharon Jane
Issue Date: 1999
School/Discipline: Dept. of Biochemistry
Abstract: Characterises the 186 coliphage site-specific integration reaction in vitro with the expectation that it could be used in mammalian systems to insert genes or modify existing ones, to provide an alternative method for the production of transgenic livestock species. The analyzed system is the temperate bacteriophage 186. The in-vitro requirements for 186 integrative site-specific recombination were investigated. In vivo investigations were conducted whereby active 186-intasomes were microinjected into fertilised mouse eggs containing genomic copies of 186-attB. The 186 system has not been shown to work in vivo.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry 1999?
Subject: Transgenic animals
Bacteriophages Genetics.
Description: Bibliography: leaves 120-138.
xi, 138, [41] leaves : ill. ; 30 cm.
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