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Type: Thesis
Title: Studies on upregulation of amyloid precursor protein in response to traumatic brain injury / Corinna Van Den Heuvel.
Author: Van Den Heuvel, Corinna
Issue Date: 1999
School/Discipline: Dept. of Pathology
Abstract: Traumatic brain injury (TBI) effects neuronal cell bodies (NCBs), axons and dendrites in a complex fashion, producing a spectrum of damage dependent on the initial injury and secondary effects. Accumulation of amyloid precursor (APP) in NSBs and axons is a feature of TBI. This accumulation may be due to impairment of the axonal transport of APP and/or upregulation of APP mRNA synthesis. This thesis hypothesizes that mechanical deformation, which is not severe enough to cause immediate cell death, results in increased APP mRNA and antigen expression as an acute phase response to injury.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 1999
Subject: Brain Wounds and injuries.
Amyloid beta-protein precursor.
Description: Appendum pasted into front end-papers.
Bibliography: leaves xiii-xliii.
xi, 195, xliii leaves : ill. (chiefly col.) ; 30 cm.
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
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