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Type: Thesis
Title: The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism / Janet K. Coller.
Author: Coller, Janet K.
Issue Date: 1999
School/Discipline: Dept. of Clinical and Experimental Pharmacology
Abstract: The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2000
Subject: Drugs Metabolism.
Genetic polymorphisms.
Description: Amendements: leaves 252-254.
Copies of author's previously published articles inserted.
Bibliography: leaves 226-251.
vi, 254 leaves : ill. ; 30 cm.
Provenance: Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.
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