Adelaide Research & Scholarship
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https://hdl.handle.net/2440/19574
| Type: | Thesis |
| Title: | The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism / Janet K. Coller. |
| Author: | Coller, Janet K. |
| Issue Date: | 1999 |
| School/Discipline: | Dept. of Clinical and Experimental Pharmacology |
| Abstract: | The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2000 |
| Subject: | Drugs Metabolism. Genetic polymorphisms. |
| Description: | Amendements: leaves 252-254. Copies of author's previously published articles inserted. Bibliography: leaves 226-251. vi, 254 leaves : ill. ; 30 cm. |
| Provenance: | Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text. This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 72.49 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 12.71 MB | Adobe PDF | View/Open | |
| Permissions Restricted Access | Library staff access only | 3.58 MB | Adobe PDF | View/Open |
| Restricted Restricted Access | Library staff access only | 15.61 MB | Adobe PDF | View/Open |
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