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Type: Thesis
Title: Mechanisms of apoptosis of colorectal cancer cells by butyrate and other preventive agents / by Fugui Chai.
Author: Chai, Fugui
Issue Date: 2001
School/Discipline: Dept. of Medicine
Abstract: The main aims of this study were firstly, to study the mechanism by which butyrate (the main fermentation product of dietary fibre) induces apoptosis of CRC cells, and secondly, to determine the effect of butyrate in combination with NSAIDs (chemopreventive agents) and other agents on apoptosis of CRC cells. For these studies LIM1215 cells and, in some experiments, SW480 cells were used. The experiments described in this thesis provided new data on the caspase-3 activation and apoptosis in butyrate-induced apoptosis of CRC cells, and the interaction of these processes with a number of cellular factors and pharmacological agents.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2001
Description: Bibliography: leaves 168-201.
xx, 202, [37] leaves, [91] leaves of plates : ill. (some col.) ; 30cm.
Provenance: Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.
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