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|Title:||Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies / Suzanne M. Froscio.|
|Author:||Froscio, Suzanne Marie|
|School/Discipline:||Dept. of Clinical and Experimental Pharmacology|
|Abstract:||The aim of this study was to determine the extent to which protein synthesis inhibition, lowered glutathione (GSH) levels and toxin metabolism contribute to the toxicity of cyclindrospermopsin. Both hepatocyte cultures and reticulocyte lysates were utilized as in vitro tools of investigation. The findings imply that the inhibition of protein synthesis by direct action of the toxin cannot be considered a primary cause of hepatocyte cell death over an acute time frame. Cytochrome P450-derived metabolites may play a crucial role in cytotoxicity, and the toxicity process does not appear to involve oxidative damage.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2002?|
|Description:||Copy of author's previously published work inserted.|
Bibliography: leaves 121-139.
xvii, 139 leaves : ill. (some col.) ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.|
|Appears in Collections:||Research Theses|
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|01front.pdf||261.36 kB||Adobe PDF||View/Open|
|02whole.pdf||7.53 MB||Adobe PDF||View/Open|
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