Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/21779
Type: Thesis
Title: Multivalent salmonella-based vaccines : consequences of prior exposure to the vector strain / Christofer John Vindurampulle.
Author: Vindurampulle, Christofer John
Issue Date: 2002
School/Discipline: Dept. of Molecular Biosciences
Abstract: Research into methods of vaccination against enteric diseases has demonstrated the advantages of using live attenuated Salmonella as carriers of foreign antigen. However, recent data have shown that prior exposure of mice to Salmonella can dramatically reduce serum antibody responses to foreign antigen subsequently delivered by the same strain. Since these findings contradict earlier reports, the aim of this thesis was to further assess the significance of pre-existing anti-vector immunity as an impediment to the Salmonella-based vaccine strategy. The results of experiments conducted strengthen concerns that pre-existing anti-vector immunity represents a serious threat to the Salmonella-based vaccine strategy.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Molecular Biosciences, 2002
Description: "April 2002"
Bibliography: leaves 143-173.
[12], 173 leaves : ill. ; 30 cm.
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
Appears in Collections:Research Theses

Files in This Item:
File Description SizeFormat 
01front.pdf73.88 kBAdobe PDFView/Open
02whole.pdf12.55 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.