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|Title:||Tolerance and resistance to organic nitrates in human blood vessels / Peter Radford Sage.|
|Author:||Sage, Peter Radford|
|School/Discipline:||Dept. of Medicine|
|Abstract:||The primary aim of the experiments described in this thesis was to investigate the mechanisms of nitrate tolerance in vessels from patients receiving a 24 hour intravenous infusion of glyceryl trinitrate at 10ug/min. The vessels studied were isolated segments of internal mammary artery and saphenous vein obtained from patients undergoing coronary bypass surgery. The results demonstrated that the presence of some risk factors for coronary artery disease may impair responses of arterial smooth muscle to glyceryl trinitrate. Furthermore, the results suggest that the mechanism underlying this resistance may be related to increased redox stress.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2002|
|Description:||Bibliography: leaves 206-241.|
xiii, 241,  leaves : ill. ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.|
|Appears in Collections:||Research Theses|
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