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Type: Thesis
Title: A lentiviral gene transfer vector for the treatment of cystic fibrosis airway disease
Author: Limberis, Maria
Issue Date: 2002
School/Discipline: Dept. of Paediatrics
Abstract: This thesis focuses on modulating the physical barriers of the airway epithelium with mild detergents, so as to enhance gene transfer by a HIV-1 based lentivirus vector in vivo. The efficiency of the gene transfer was evaluated in the nasal airway of C57B1/6 mice using the Lac Z marker gene. This demonstration of lentivirus-mediated in vivo recovery of CFTR function in CF airway epithelium illustrated the potential of combining a pre-conditioning of the airway surface with a simple and brief HIV-1 based gene transfer vector exposure to produce therapeutic gene expression in the intact airway.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2003
Subject: Cystic fibrosis Gene therapy.
Genetic transformation.
Genetic vectors
Description: "16th September 2002."
Accompanying CD contains 2 MPEG clips with accompanying text, and a copy in PDF format of: Recovery of airway cystic fibrosis transmembrane conductance regulator function in mice with cystic fibrosis after single-dose lentivirus-mediated gene transfer / M. Limberis ... [et al.], published in Human gene therapy vol. 13 (2002).
Bibliography: leaves xxix-li.
xxvii, 213, li leaves : ill., plates (some col.) ; 30 cm. + 1 CD-ROM (4 3/4 in.)
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