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Type: Thesis
Title: Ethanol teratogenicity : the aetiological importance of zinc and metallothionein / by Luke Charles Carey.
Author: Carey, Luke Charles
Issue Date: 2002
School/Discipline: Dept. of Physiology
Abstract: Changes in maternal-foetal zinc homeostasis resulting in a foetal deficiency may be an important contributing factor in ethanol-realted teratogenicity. Ethanol induces expression of hepatic metallothionein, causing zinc transfer from the plasma to the liver. Rodent studies show that changes in plasma zinc correlate with a high incidence of abnormal fetuses in MT+/+ mice. Demonstrates a clear link between maternal hepatic MT induction, decreased foetal zinc supply, and teratogenicity, which has major implications for binge alcohol consumption in early pregnancy. The demonstration that zinc treatment is effective in preventing teratogenicity indicates potential treatment strategies.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 2003
Subject: Fetal alcohol syndrome Animal models.
Zinc in the body Animal models.
Alcohol Toxicology Animal models.
Metallothionein Physiological effect Animal models.
Description: "August 2002"
Bibliography: leaves 141-176.
ix, 179 leaves : ill. (some col.) ; 30 cm
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