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|Title:||Immunogenetic determinants of chronic Q fever / Karla Jayne Helbig.|
|Author:||Helbig, Karla Jayne|
|School/Discipline:||Dept. of Pathology|
|Abstract:||Q fever, caused by the bacterium Coxiella burnetti, is the most important and costly zoonotic infection in Australia. It manifests in both acute and chronic forms, with the majority of acute Q fever patients making a complete recovery. The strain of C. burnetti has not been found to play a role in the development of chronic Q fever, and it remains unclear why a minority of individuals manifest chronic forms of Q fever, while others make a complete recovery. This study attempts to elucidate possible immunogenetic markers that may contribute to an individual's risk of developing chronic Q fever, as well as attempting to gain a better understanding of the pathophysiological roles that certain variants of immune response genes may play in chronic Q fever. It is shown that the development of chronic Q fever conditions following an acute attack of Q fever have a genetic component, affecting those genes involved in the immune response. The immunogenetic predisposition to chronic Q fever is explored, and reveals important new associations that may help to increase the understanding of these chronic conditions.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 2003|
Bibliography: leaves 213-244.
xvi, 244 leaves : ill. (some col.) ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.|
|Appears in Collections:||Research Theses|
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