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Type: Thesis
Title: The role of apoptosis in the pathogenesis of chronic obstructive pulmonary disease / Sandra Joy Hodge.
Author: Hodge, Sandra Joy
Issue Date: 2003
School/Discipline: Dept. of Medicine
Abstract: In chronic obstructive pulmonary disease (COPD) there is inadequate repair of the chronically damaged and inflamed airway epithelium. There is a school of thought that this inadequate repair may result from an accumulation of apoptotic material in the airways, resulting in secondary necrosis, tissue destruction and chronic inflammation. This thesis is an investigation of apoptosis and clearance of apoptotic cells on COPD using samples of peripheral blood, and bronchial brushings and bronchial lavage obtained from the airways during fibreoptic bronchoscopy. It also describes the development of a number of new methods to investigate the biologic specimens. The findings from this thesis indicate that failure to resolve epithelial damage and chronic inflammation in COPD may result, at least partially from increased apoptosis, increased activation of apoptotic pathways and defective clearance of apoptopic material by alveolar macrophages.
Dissertation Note: Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003
Description: "April 2003"
Bibliography: leaves 268-290.
xix, 290 leaves : ill. (some col.) ; 30 cm.
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
Appears in Collections:Research Theses

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