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|Title:||Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.|
|Author:||Coates, Deborah Patricia|
|School/Discipline:||School of Molecular and Biomedical Science|
|Abstract:||This thesis aimed to characterise the G1-S phase role of Drosophila Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor from this screen, Su(DmcycEjp)2.5, was identified as a potential Drosophila homologue of the microtubule binding protein Eb1, dEb1. Southern and northern analysis confirmed that Su(DmcycEjp)2.5 is an allele of dEb1, and other dEb1 alleles were shown to also be able to suppress cyclin Ejp.|
|Dissertation Note:||Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, 2003|
Bibliography: p. 189-196.
xv, 196 p. : ill. (some col.), plates (col.) ; 30 cm.
|Provenance:||This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals|
|Appears in Collections:||Research Theses|
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|02whole.pdf||12.63 MB||Adobe PDF||View/Open|
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