Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/22727
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVoss, L.en
dc.contributor.authorLudbrook, G.en
dc.contributor.authorGrant, C.en
dc.contributor.authorSleigh, J.en
dc.contributor.authorBarnard, J.en
dc.date.issued2006en
dc.identifier.citationActa Anaesthesiologica Scandinavica, 2006; 50(3):313-319en
dc.identifier.issn0001-5172en
dc.identifier.issn1399-6576en
dc.identifier.urihttp://hdl.handle.net/2440/22727-
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstractBackground:  Different volatile anesthetic agents have differing propensities for inducing seizures. A measure of the predilection to develop seizures is the presence of interictal spike discharges (spikes) on the electrocorticogram (ECoG). In this study, we investigated the propensity of desflurane to induce cortical spikes and made a direct objective comparison with enflurane, isoflurane, and sevoflurane. The ECoG effects of desflurane have not been previously reported. Methods:  After establishment of invasive monitoring and a parasagittal array of eight electrodes to record the ECoG; eight adult merino sheep were given a series of short inhalational anesthetics (using desflurane, enflurane, sevoflurane and isoflurane); each titrated to ECoG burst suppression. Anesthetic effect was estimated by the effects on the approximate entropy of the ECoG. The effect of anesthetic on the spike-rate in the ECoG was analyzed using a non-linear mixed-effect method with a sigmoid Emax model. Results:  A similar `depth of anesthesia' was achieved for each agent, as estimated by the approximate entropy. The mean (SD) values of Emax for the spike-rate vs. approximate entropy relationship were desflurane 0.5 (0.9), enflurane 17.2 (4.0), isoflurane 0.7 (1.2), and sevoflurane 5.3 (1.2) spikes/min. The spike rate caused by desflurane was similar to isoflurane and significantly lower than that of enflurane (P < 0.001), and sevoflurane (P = 0.009). Conclusion:  Desflurane induces minimal cerebral cortical spike activity when administered to burst suppression, consistent with its low propensity for inducing seizures in non-epileptic brains. The agents can be ranked by their relative ability to cause spike activity: enflurane >> sevoflurane > isoflurane = desflurane.en
dc.description.statementofresponsibilityVoss, L.J.; Ludbrook, G.; Grant, C.; Sleigh, J.W. and Barnard, J.P.M.en
dc.language.isoenen
dc.publisherMunksgaard Int Publ Ltden
dc.subjectvolatile anesthetics; epileptogenesis; seizures; sheep; entropyen
dc.titleCerebral cortical effects of desflurane in sheep: comparison with isoflurane, sevoflurane and enfluraneen
dc.typeJournal articleen
dc.identifier.rmid0020060057en
dc.identifier.doi10.1111/j.1399-6576.2006.00914.xen
dc.identifier.pubid53274-
pubs.library.collectionAnaesthesia and Intensive Care publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLudbrook, G. [0000-0001-6925-4277]en
Appears in Collections:Anaesthesia and Intensive Care publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.