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Type: Journal article
Title: Synthesis and biological activity of allosteric modulators of GABA(B) receptors, Part 2. 3-(2,6-bis-tert-butyl-4-hydroxyphenyl)propanols
Author: Kerr, D.
Khalafy, J.
Ong, J.
Perkins, M.
Prager, R.
Puspawati, N.
Rimaz, M.
Citation: Australian Journal of Chemistry, 2006; 59(7):457-462
Publisher: C S I R O Publishing
Issue Date: 2006
ISSN: 0004-9425
Statement of
David I. B. Kerr, Jabbar Khalafy, Jennifer Ong, Michael V. Perkins, Rolf H. Prager, Ni Made Puspawati and Mehdi Rimaz
Abstract: A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan-1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4–7 μM) was greatest for the cyclohexyl and cyclopentyl analogues.
Rights: © CSIRO 2006
RMID: 0020061185
DOI: 10.1071/CH06164
Appears in Collections:Anaesthesia and Intensive Care publications

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