Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/22798
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Type: Journal article
Title: Cyanobacterial (Blue-Green algal) toxins in water supplies: Cylindrospermopsins
Author: Falconer, I.
Humpage, A.
Citation: Environmental Toxicology, 2006; 21(4):299-304
Publisher: John Wiley & Sons Inc
Issue Date: 2006
ISSN: 1520-4081
1522-7278
Abstract: The toxic alkaloid cylindrospermopsin is produced by a range of cyanobacterial species worldwide. It was first identified in the species Cylindrospermopsis raciborskii from tropical waters, and has since been isolated from four other genera in locations ranging from Israel to Japan. High concentrations of the organisms and toxin have been identified in reservoirs, natural lakes, and rivers in summer in the USA and in Australia. The toxin is a particular problem in drinking water sources as concentrations in the free water are appreciable, so that removal of the filaments during water treatment does not remove the toxin. The toxicity resulting from oral ingestion is seen in the liver, kidneys, stomach, intestine, and white blood cells, with some vascular damage in mice. Gastrointestinal as well as liver injury has been observed in human poisoning. Studies of toxicity in vitro have shown inhibition of protein synthesis. Genotoxicity has also been demonstrated, and there is preliminary evidence for carcinogenicity. A Guideline Value for safe water supply of 1 microg/L has been proposed. Research into toxin measurement techniques and water treatment methods has indicated that effective control measures may be practicable for this toxin in drinking water. Considerably more research is needed to fully define the health risks from this toxin.
Keywords: Cyanobacteria
Water
Alkaloids
Uracil
Bacterial Toxins
Water Pollutants, Chemical
Carcinogens
Water Microbiology
Environmental Monitoring
Water Purification
DOI: 10.1002/tox.20194
Appears in Collections:Aurora harvest 2
Environment Institute publications
Pharmacology publications

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