Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/22857
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Type: Journal article
Title: Theoretical modeling of micro-scale biological phenomena in human coronary arteries
Author: Wong, K.
Mazumdar, J.
Pincombe, B.
Worthley, S.
Sanders, P.
Abbott, D.
Citation: Medical & Biological Engineering & Computing, 2006; 44(11):971-982
Publisher: Peter Peregrinus Ltd
Issue Date: 2006
ISSN: 0140-0118
1741-0444
Statement of
Responsibility: 
Kelvin Wong, Jagannath Mazumdar, Brandon Pincombe, Stephen G. Worthley, Prashanthan Sanders and Derek Abbott
Abstract: This paper presents a mathematical model of biological structures in relation to coronary arteries with atherosclerosis. A set of equations has been derived to compute blood flow through these transport vessels with variable axial and radial geometries. Three-dimensional reconstructions of diseased arteries from cadavers have shown that atherosclerotic lesions spiral through the artery. The theoretical framework is able to explain the phenomenon of lesion distribution in a helical pattern by examining the structural parameters that affect the flow resistance and wall shear stress. The study is useful for connecting the relationship between the arterial wall geometries and hemodynamics of blood. It provides a simple, elegant and non-invasive method to predict flow properties for geometrically complex pathology at micro-scale levels and with low computational cost.
Keywords: Atherosclerosis; Axial and radial asymmetry; Spiraling lesion; Resistance to flow ratio; Wall shear stress
Description: The original publication is available at www.springerlink.com
RMID: 0020061473
DOI: 10.1007/s11517-006-0113-6
Published version: http://www.springerlink.com/content/728l5765011256g4/?p=0e77959c6388442399c0b03d62dd4f80&pi=0
Appears in Collections:Electrical and Electronic Engineering publications

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