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Type: Journal article
Title: Theoretical modeling of micro-scale biological phenomena in human coronary arteries
Author: Wong, K.
Mazumdar, J.
Pincombe, B.
Worthley, S.
Sanders, P.
Abbott, D.
Citation: Medical and Biological Engineering and Computing, 2006; 44(11):971-982
Publisher: Peter Peregrinus Ltd
Issue Date: 2006
ISSN: 0140-0118
Statement of
Kelvin Wong, Jagannath Mazumdar, Brandon Pincombe, Stephen G. Worthley, Prashanthan Sanders and Derek Abbott
Abstract: This paper presents a mathematical model of biological structures in relation to coronary arteries with atherosclerosis. A set of equations has been derived to compute blood flow through these transport vessels with variable axial and radial geometries. Three-dimensional reconstructions of diseased arteries from cadavers have shown that atherosclerotic lesions spiral through the artery. The theoretical framework is able to explain the phenomenon of lesion distribution in a helical pattern by examining the structural parameters that affect the flow resistance and wall shear stress. The study is useful for connecting the relationship between the arterial wall geometries and hemodynamics of blood. It provides a simple, elegant and non-invasive method to predict flow properties for geometrically complex pathology at micro-scale levels and with low computational cost.
Keywords: Atherosclerosis
Axial and radial asymmetry
Spiraling lesion
Resistance to flow ratio
Wall shear stress
Description: The original publication is available at
DOI: 10.1007/s11517-006-0113-6
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Appears in Collections:Aurora harvest 6
Electrical and Electronic Engineering publications

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