Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPant, H.en
dc.contributor.authorKette, F.en
dc.contributor.authorSmith, W.en
dc.contributor.authorMacardle, P.en
dc.contributor.authorWormald, P.en
dc.identifier.citationLaryngoscope, 2006; 116(7):1241-1247en
dc.description© The American Laryngological, Rhinological & Otological Society, Inc.en
dc.description.abstractBackground: Eosinophilic mucus chronic rhinosinusitis (EMCRS) can be subclassified using the criteria of detection of fungi in eosinophilic mucus and systemic fungal allergy. Allergic fungal sinusitis (AFS), a subgroup of EMCRS characterized by the presence of fungal allergy, is proposed to be an immunoglobulin (Ig)E-driven disease, distinct from other EMCRS subgroups. However, our recent studies cast doubt on the central pathogenic role of allergy in AFS. The purpose of this study was to examine the clinical features of EMCRS patients from the different subcategories to determine the relevance of this classification system. Method: The demographic, clinical, and immunologic characteristics of the EMCRS subgroups were examined prospectively and compared with three control groups: healthy volunteers, allergic rhinitis with fungal allergy, and chronic rhinosinusitis without eosinophilic mucus. Results: EMCRS patients with allergy were younger than those without. There was no significant difference in clinicopathologic parameters between EMCRS subgroups. As a single group, EMCRS had a more severe sinus disease compared with chronic rhinosinusitis patients. Conclusions: AFS was not clinically distinct from other subgroups of EMCRS. However, eosinophilic mucus may mark a more severe and distinct form of sinus disease.en
dc.description.statementofresponsibilityPant, Harshita; Kette, Frank E.; Smith, William B.; Macardle, Peter J. and Wormald, Peter J.en
dc.publisherLippincott Williams & Wilkinsen
dc.subjectParanasal Sinuses; Mucus; Humans; Fungi; Mycoses; Sinusitis; Rhinitis; Eosinophilia; Chronic Disease; Antibodies, Fungal; Diagnosis, Differential; Tomography, X-Ray Computed; Follow-Up Studies; Prospective Studies; Adult; Aged; Middle Aged; Female; Maleen
dc.titleEosinophilic mucus chronic rhinosinusitis: Clinical subgroups or a homogeneous pathogenic entity?en
dc.typeJournal articleen
pubs.library.collectionSurgery publicationsen
dc.identifier.orcidWormald, P. [0000-0001-7753-7277]en
Appears in Collections:Surgery publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.