Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: The optimal SAM surface functional group for producing a biomimetic HA coating on Ti
Author: Liu, D.
Majewski, P.
O'Neill, B.
Ngothai, Y.
Colby, C.
Citation: Journal of Biomedical Materials Research Part A, 2006; 77A(4):763-772
Publisher: John Wiley & Sons, Inc.
Issue Date: 2006
ISSN: 1549-3296
Statement of
D. P. Liu, P. Majewski, B. K. O’Neill, Y. Ngothai and C. B. Colby
Abstract: Commercial interest is growing in biomimetic methods that employ self assembled mono-layers (SAMs) to produce biocompatible HA coatings on Ti-based orthopedic implants. Recently, separate studies have considered HA formation for various SAM surface functional groups. However, these have often neglected to verify crystallinity of the HA coating, which is essential for optimal bioactivity. Furthermore, differing experimental and analytical methods make performance comparisons difficult. This article investigates and evaluates HA formation for four of the most promising surface functional groups: --OH, --SO(3)H, --PO(4)H(2) and --COOH. All of them successfully formed a HA coating at Ca/P ratios between 1.49 and 1.62. However, only the --SO(3)H and --COOH end groups produced a predominantly crystalline HA. Furthermore, the --COOH end group yielded the thickest layer and possessed crystalline characteristics very similar to that of the human bone. The --COOH end group appears to provide the optimal SAM surface interface for nucleation and growth of biomimetic crystalline HA. Intriguingly, this finding may lend support to explanations elsewhere of why human bone sialoprotein is such a potent nucleator of HA and is attributed to the protein's glutamic acid-rich sequences.
Keywords: biocompatibility
biomimetic material
hydroxyapatite coating
orthopedic implant
self-assembled monolayer
Rights: Copyright © 2006 Wiley Periodicals, Inc.
DOI: 10.1002/jbm.a.30641
Published version:
Appears in Collections:Aurora harvest 2
Chemical Engineering publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.